High-Functioning Autism and Comorbid Conditions Overview

High-functioning autism comorbidity often includes ADHD, OCD, or anxiety; discover practical ways to support unique strengths and challenges.

October 24, 2025

Autism can feel like its own universe. But here’s something many don’t know: high-functioning autism comorbidity often comes with other conditions, making that universe even more complex. People with high-functioning autism (HFA) frequently face additional challenges alongside their autism, adding layers to daily life. Understanding these comorbidities helps us see the full range of strengths and struggles autistic individuals experience. How common are these co-occurring conditions, and what might they look like in real life? Research shows that anxiety, ADHD, OCD, and epilepsy can all appear alongside HFA, shaping how autistic people experience the world and how support strategies are designed (Nahar et al., 2019; Barlattani et al., 2023). Keep reading to explore these insights in detail.

High-Functioning Autism Comorbidity: What the Numbers Reveal

  • Around 17% of autistic individuals may also have OCD (van Steensel et al., 2011).
  • Intellectual disability appears in approximately 56% of cases (Watanabe et al., 2017).
  • ADHD affects 30%–50% of autistic individuals (Leitner, 2014).
  • Epilepsy is present in roughly 20% (Besag, 2018).
  • Gastrointestinal issues can impact up to 79% (Mannion et al., 2013).
  • About 79% of autistic adults report mental health challenges like depression (Autistica, 2023).

Autism and Obsessive-Compulsive Disorder

Did you know that repetitive behaviors in autism can sometimes look like OCD? This is where high-functioning autism comorbidity gets particularly intriguing. While both autistic individuals and those with OCD display repeated actions, the underlying reasons differ. Autistic routines often serve self-regulation or sensory enjoyment. In OCD, repetition stems from anxiety or intrusive thoughts, creating distress (Russell et al., 2016).

Research shows that approximately 17% of autistic individuals meet criteria for OCD (van Steensel et al., 2011). Imagine someone organizing objects meticulously, not out of fear, but because the order feels comforting. Contrastingly, someone with OCD might organize in a way that temporarily relieves intense worry. Understanding this distinction helps clinicians provide supportive interventions that respect both the autism and OCD aspects of the individual.

Autism and Intellectual Disability

High-functioning autism might suggest “normal intelligence,” but it doesn’t exclude intellectual challenges. Many autistic people display spiky cognitive profiles, excelling in some areas while struggling in others. Intellectual disability co-occurs in about 32–56% of autistic individuals depending on the assessments used (Baio et al., 2018; Watanabe et al., 2017).

The Valuing People UK White Paper (2000) defines intellectual disability as:

  • Difficulty understanding new or complex information, with challenges in learning new skills.
  • Reduced ability to cope independently in social contexts.

For example, a student might master math quickly yet struggle with daily living skills like cooking or budgeting. Recognizing the spiky nature of abilities allows for targeted support that nurtures strengths while addressing areas of need.

Autism and ADHD

When high-functioning autism meets ADHD, what happens? You get an intriguing mix of traits. ADHD affects 30–50% of autistic individuals (Leitner, 2014). Both conditions influence executive functioning, but often in opposing ways. Autism may crave routine and focus, while ADHD drives shifts in attention and impulsivity (Colombi & Ghaziuddin, 2017).

Here’s what that might look like in daily life:

  • Difficulty planning or prioritizing tasks.
  • Trouble sustaining focus on uninteresting activities.
  • Impulsivity conflicting with a desire for routine.
  • Challenges with memory, sequencing, and organization.

The combination of these traits can amplify the unique experiences of autistic individuals, highlighting why tailored strategies for executive function are crucial.

Autism and Schizophrenia

Autism and schizophrenia are distinct but occasionally overlapping in presentation. Both may involve social withdrawal, communication challenges, and eye contact difficulties. Yet, schizophrenia often includes psychosis, hallucinations, or delusions, which are not features of autism (Nahar et al., 2019).

For example, an autistic adult might prefer solitude and struggle with nuanced social cues, while someone with schizophrenia might misinterpret reality entirely. Clinicians need specialized training to distinguish these characteristics, ensuring that interventions address each condition accurately.

Autism and Epilepsy

Epilepsy is surprisingly common among autistic individuals, affecting roughly 20% (Hara, 2007; Besag, 2018). Seizures may begin between ages 8 and 26, presenting as partial or generalized types. Partial seizures may or may not alter consciousness, whereas generalized seizures could include massive myoclonic events that appear dramatic but are manageable with treatment.

Consider a teenager who experiences sudden muscle jerks, knowing these are seizures rather than typical behaviors can change how school staff and peers respond. Early recognition and medication management make a significant difference in safety and quality of life.

Autism and Gastrointestinal Disorders

Did you know many autistic individuals have gut issues? Up to 79% of autistic children may experience gastrointestinal symptoms (Mannion et al., 2013). These can include:

  • Chronic constipation.
  • Abdominal pain.
  • Gastroesophageal reflux.
  • Bowel inflammation.

GI issues often affect mood and comfort, impacting behavior and learning. Understanding the body’s signals can improve day-to-day well-being, making it easier for individuals to engage in routines and activities they enjoy.

Autism and Feeding Challenges

Feeding issues are common. Around 70% of autistic children show atypical eating behaviors, including food selectivity, texture aversions, and, in some cases, pica (Nebel-Schwalm & Worley, 2014). These behaviors often arise from sensory sensitivities or a need for consistency.

For example, a child might refuse green vegetables but eat a particular brand of pasta daily. With supportive strategies, such as gradual exposure to new textures, feeding challenges can become manageable without distressing the individual.

Autism and Sleep

Sleep disruptions are common among autistic children and adults. Difficulty falling asleep, staying asleep, or getting restful sleep can impact daily functioning and may worsen behavioral and cognitive challenges.

Strategies that work include:

  • Consistent bedtime routines.
  • Environmental adjustments like dim lights and quiet rooms.
  • Cognitive-behavioral approaches tailored for autism.

Even small improvements in sleep can create remarkable changes in mood, focus, and overall quality of life.

Autism and Anxiety

Anxiety is a common experience for children and adolescents with autism spectrum disorders, affecting daily functioning and emotional well-being (White et al., 2009). Social anxiety is particularly prevalent, often triggered by unfamiliar people or environments. Physical signs may include a racing heart, muscle tension, or feeling “frozen.”

Behavioral strategies, such as cognitive-behavioral therapy adapted for autism, provide effective support. Some individuals may benefit from anti-anxiety medication, under professional guidance, when anxiety becomes overwhelming.

Autism and Depression

Autism and depression frequently co-occur, highlighting the importance of understanding their interconnected effects on mental health (van Heijst et al., 2020). Autistic individuals may hide or mask depressive symptoms, yet certain observable changes can still be noticed:

  • Loss of interest in favorite activities.
  • Changes in hygiene or appetite.
  • Chronic feelings of sadness or hopelessness.

Tailored therapy and supportive interventions can help manage depression, allowing individuals to engage fully with life and relationships.

Autism and Bipolar Disorder

Comorbidity of autism spectrum disorder (ASD) and bipolar disorder (BD) affects an estimated 7% of individuals with ASD, posing diagnostic challenges and highlighting the need for tailored treatment strategies (Dunalska et al., 2021). Furthermore, differentiating autism-related energy from mania is essential. A child with autism may be consistently high-energy, whereas mania in bipolar disorder involves episodic, extreme mood changes.

Medication and therapy need careful consideration, as some standard treatments may affect autistic individuals differently. Psychiatric guidance ensures interventions are safe and effective.

Executive Function Challenges

Executive function, planning, organization, flexibility, and self-regulation, can be affected in high-functioning autism (Bennetto et al., 1996; Ozonoff, 1998). Tools like the Wisconsin Card Sorting Test reveal challenges in task switching and problem-solving.

Consider a college student with HFA juggling assignments. Executive function challenges may manifest as difficulty prioritizing, completing tasks, or adapting to unexpected changes. Recognizing these patterns enables tailored support strategies, emphasizing strengths while addressing specific challenges.

Managing High-Functioning Autism

Though individuals with high-functioning autism often live independently, tailored support enhances quality of life. Effective strategies include:

  • Cognitive behavioral therapy for anxiety, depression, and OCD
  • Medication when indicated for seizures or mood disorders
  • Executive function coaching for organization, planning, and flexibility
  • Structured routines and visual supports

By addressing both autism characteristics and comorbid conditions, interventions empower individuals to navigate life successfully.

FAQ

1. Can someone have high-functioning autism without any comorbid conditions?

Yes, while common, comorbid conditions are not universal. Some individuals show typical development in areas outside core autism traits.

2. How can OCD be distinguished from repetitive behaviors in autism?

OCD behaviors are usually driven by anxiety and distress. Autism-related behaviors often provide comfort or self-regulation (van Steensel et al., 2011).

3. Is ADHD treatment different for someone with high-functioning autism?

Yes. Interventions must account for autism-related routines and sensory sensitivities alongside ADHD symptoms (Colombi & Ghaziuddin, 2017).

4. Can executive function coaching help adults with high-functioning autism?

Absolutely. Strategies like structured schedules, visual aids, and task breakdowns improve planning, organization, and self-regulation (Ozonoff, 1998).

5. Are sleep and GI issues connected to autism severity?

Often, yes. Sensory sensitivities and rigid routines can influence sleep and digestive patterns, impacting behavior and overall health (Mannion et al., 2013).

Celebrating Unique Strengths and Building Pathways to Success

High-functioning autism is both fascinating and complex. Many people also experience comorbidities like OCD, intellectual disability, ADHD, epilepsy, gastrointestinal issues, anxiety, depression, bipolar disorder, or Down syndrome. New Dawn ABA in Missouri helps families navigate these challenges with care and expertise. Each condition adds layers to a person’s profile. Looking at them positively lets clinicians, educators, and caregivers design support that respects both the autism and any co-occurring condition.

When comorbidities are identified and addressed, people with high-functioning autism can thrive. They can use their strengths while managing challenges more effectively. Every individual shows a unique mix of traits, and embracing this diversity opens doors to growth, confidence, and success.

Families or caregivers in Missouri seeking guidance can reach out to New Dawn ABA for personalized strategies that truly make a difference.